Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait
Jones E., Pasricha S-R., Allen A., Evans P., Fisher CA., Wray K., Premawardhena A., Bandara D., Perera A., Webster C., Sturges P., Olivieri NF., St. Pierre T., Armitage AE., Porter JB., Weatherall DJ., Drakesmith H.
Key Points Expanded erythropoiesis strongly drives hepcidin suppression in severe transfusion-dependent HbE β-thalassemia. β-thalassemia carriers, but not HbE carriers, have enhanced erythropoiesis associated with mildly suppressed hepcidin.